Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85 Study

Abstract

We investigated the frequency of Lewy-related pathology (LRP) in the amygdala among the population-based Vantaa 85 study. Data of amygdala samples (N=304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with the previously analyzed LRP and AD pathologies from other brain regions. The amygdala LRP was present in one third (33) of subjects. Only 5 of pure AD subjects, but 85 of pure DLB subjects had LRP in the amygdala. The amygdala LRP was associated with dementia; however, the association was dependent on LRP on other brain regions, and thus was not an independent risk factor. The amygdala-predominant category was a rare (4) and heterogeneous group.