Selectins and their counter receptors: A bitter sweet attraction

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Abstract

Selectins are adhesion receptors expressed by leucocytes, platelets, and endothelial cells. They mediate the initial binding of leucocytes to vascular endothelium in the post-capillary venules. This is an essential first step in leucocyte migration into tissue. The selectin family of adhesion receptors consists of three C-type lectins (E, P, and L selectin). Their ligand (counter structures) are sialylated and fucosylated carbohydrate molecules which, in most cases, decorate mucin-like glycoprotein membrane receptors. Studies using blocking monoclonal antibodies have shown that inhibition of selectin function can ameliorate a range of inflammatory processes, offering the possibility that antagonists of selectin function may be useful in the treatment of inflammatory lung diseases such as asthma.

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Symon, F. A., & Wardlaw, A. J. (1996). Selectins and their counter receptors: A bitter sweet attraction. Thorax. BMJ Publishing Group. https://doi.org/10.1136/thx.51.11.1155

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