Estimating equations for biomarker based exposure estimation under non-steady-state conditions

2Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Unrealistic steady-state assumptions are often used to estimate toxicant exposure rates from biomarkers. A biomarker may instead be modeled as a weighted sum of historical time-varying exposures. Estimating equations are derived for a zero-inflated gamma distribution for daily exposures with a known exposure frequency. Simulation studies suggest that the estimating equations can provide accurate estimates of exposure magnitude at any reasonable sample size, and reasonable estimates of the exposure variance at larger sample sizes. © 2011 Bartell and Johnson; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Bartell, S. M., & Johnson, W. O. (2011). Estimating equations for biomarker based exposure estimation under non-steady-state conditions. Environmental Health: A Global Access Science Source, 10(1). https://doi.org/10.1186/1476-069X-10-57

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free