Modulation of glial responses by furanocembranolides: Leptolide diminishes microglial inflammation in vitro and ameliorates gliosis in vivo in a mouse model of obesity and insulin resistance

2Citations
Citations of this article
33Readers
Mendeley users who have this article in their library.

Abstract

Neurodegenerative diseases are age-related disorders caused by progressive neuronal death in different regions of the nervous system. Neuroinflammation, modulated by glial cells, is a crucial event during the neurodegenerative process; consequently, there is an urgency to find new therapeutic products with anti-glioinflammatory properties. Five new furanocembranolides (1-5), along with leptolide, were isolated from two different extracts of Leptogorgia sp., and compound 6 was obtained from chemical transformation of leptolide. Their structures were determined based on spectroscopic evidence. These seven furanocembranolides were screened in vitro by measuring their ability to modulate interleukin-1β (IL-1β) production by microglial BV2 cells after LPS (lipopolysaccharide) stimulation. Leptolide and compounds 3, 4 and 6 exhibited clear anti-inflammatory effects on microglial cells, while compound 2 presented a pro-inflammatory outcome. The in vitro results prompted us to assess anti-glioinflammatory effects of leptolide in vivo in a high-fat diet-induced obese mouse model. Interestingly, leptolide treatment ameliorated both microgliosis and astrogliosis in this animal model. Taken together, our results reveal a promising direct biological effect of furanocembranolides on microglial cells as bioactive anti-inflammatory molecules. Among them, leptolide provides us a feasible therapeutic approach to treat neuroinflammation concomitant with metabolic impairment.

Cite

CITATION STYLE

APA

Corraliza-Gomez, M., Gallardo, A. B., Diaz-Marrero, A. R., De La Rosa, J. M., D’Croz, L., Darias, J., … Cueto, M. (2020). Modulation of glial responses by furanocembranolides: Leptolide diminishes microglial inflammation in vitro and ameliorates gliosis in vivo in a mouse model of obesity and insulin resistance. Marine Drugs, 18(8). https://doi.org/10.3390/MD18080378

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free