Diastereoselective synthesis of cyclopentanediols by InCl3/Al mediated intramolecular pinacol coupling reaction in aqueous media

Abstract

A "green" and practical intramolecular pinacol coupling reaction promoted by InCl3/Al catalysts in aqueous media has been developed. Under mild conditions, a novel class of polysubstituted cyclopentane-1,2-diols have been obtained with excellent diastereoselectivity. © 2008 by the authors; licensee Molecular Diversity Preservation International.