Fermented Noni Exudate (fNE): A mediator between immune system and anti-tumor activity

24Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.

Abstract

The anti-tumor activity of Morinda citrifolia fruit juice (Noni) has been previously reported. However, the mechanism behind this activity remains unknown. In the present study, we studied the anti-tumor activity of fermented Noni exudate (fNE) and demonstrated that intraperitoneal injection of this material significantly increased the percentages of granulocytes and NK cells in the peripheral blood, peritoneum, and spleen. Furthermore, in preventive and treatment settings, fNE injection induced complete tumor rejection in normal C57BL/ 6J mice, partial tumor rejection in C57 nude mice lacking functional lymphocytes, and no tumor rejection in NK cell deficient beige mice. Over 85% of the C57BL/6J mice that received fNE survived the first tumor injection and rejected up to 5×106 tumor cells when re-challenged. The anti-tumor activity remains in the heat-inactivated and filtrated supernatant of fNE. These data demonstrate that fNE appears to be able to stimulate the innate immune system and the adaptive immune system to reject tumor cells. NK cells respond quickly and appear to be among the major players of the innate immune system, while the adaptive immune system reacts later with a retained memory.

References Powered by Scopus

An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity

197Citations
N/AReaders
Get full text

Cancer preventive effect of Morinda citrifolia (Noni)

181Citations
N/AReaders
Get full text

From Polynesian healers to health food stores: Changing perspectives of Morinda citrifolia (Rubiaceae)

168Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Edible Medicinal and Non-Medicinal Plants: Volume 5, Fruits

180Citations
N/AReaders
Get full text

Morinda citrifolia (Noni): A comprehensive review on its industrial uses, pharmacological activities, and clinical trials

165Citations
N/AReaders
Get full text

Properties and Applications of Morinda citrifolia (Noni): A Review

115Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Li, J., Stickel, S. L., Bouton-Verville, H., Burgin, K. E., Yu, X., Wong, D. K. W., … Wei, Y. (2008). Fermented Noni Exudate (fNE): A mediator between immune system and anti-tumor activity. Oncology Reports, 20(6), 1505–1509. https://doi.org/10.3892/or_00000172

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 8

50%

Lecturer / Post doc 4

25%

Professor / Associate Prof. 2

13%

Researcher 2

13%

Readers' Discipline

Tooltip

Pharmacology, Toxicology and Pharmaceut... 4

29%

Agricultural and Biological Sciences 4

29%

Chemistry 3

21%

Biochemistry, Genetics and Molecular Bi... 3

21%

Save time finding and organizing research with Mendeley

Sign up for free