The liver under the spotlight: Bile acids and oxysterols as pivotal actors controlling metabolism

Abstract

Among the myriad of molecules produced by the liver, both bile acids and their precur-sors, the oxysterols are becoming pivotal bioactive lipids which have been underestimated for a long time. Their actions are ranging from regulation of energy homeostasis (i.e., glucose and lipid metabolism) to inflammation and immunity, thereby opening the avenue to new treatments to tackle metabolic disorders associated with obesity (e.g., type 2 diabetes and hepatic steatosis) and inflammatory diseases. Here, we review the biosynthesis of these endocrine factors including their interconnection with the gut microbiota and their impact on host homeostasis as well as their attrac-tive potential for the development of therapeutic strategies for metabolic disorders.