Clinical presentation

Abstract

The symptoms and signs caused by MS mirror the casual and widespread distribution of the focal as well of the diffuse damage caused by inflammatory and degenerative processes of the disease. Therefore, every symptom and sign connected with a lesion of the central nervous system can appear in MS patients. However, some disturbances happen more frequently, such as optic nerve damage, pyramidal, cerebellar and somatic sensory systems involvement. Other dysfunctions (i.e., vegetative disturbances) are rare at the disease onset, but can be found in the vast majority of patients after some years of disease course. Symptoms like fatigue are difficult to be set but are undoubtedly frequent and are considered as more disabling than others by patients themselves.