Role of PPAR-d in diabetic cardiomyopathy

Abstract

Although diabetics are at increased risk of structural heart disease from vascular complications, the concept of diabetic cardiomyopathy suggests a direct cellular insult to the myocardium. Several investigations, mainly echocardiographic population-based studies, documented a uniform association between diabetic cardiomyopathy and the presence of cardiac hypertrophy and myocardial stiffness. In the following review, we attempt to provide a comprehensive insight to discuss the possible underlying mechanisms, especially the role of PPARs in diabetic cardiomyopathy.