Noncoding RNAs are key players in the regulation of complex cellular processes. Over the years, it has been demonstrated that their abnormal expression is associated with many human pathologies including developmental and neurobehavioral disorders, diabetes, obesity, and cancer. A wide spectrum of activities and a large number of genes that are regulated by RNA-dependent mechanisms makes the ncRNA molecules attractive targets for developing next generation therapeutic agents. This chapter outlines the principles of RNA regulation, the involvement of various RNAs in human diseases, and the strategies of application of ncRNA-targeted therapeutic approaches.
CITATION STYLE
Szymański, M., & Barciszewski, J. (2010). Noncoding RNAs as Therapeutic Targets. In RNA Technologies (pp. 393–418). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-642-12168-5_18
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