Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection

15Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

DNA methyltransferase (DNMT) 1 is the key enzyme responsible for DNA methylation, which often occurs in CpG islands located near the regulatory regions of genes and affects transcription of specific genes. In this study, we examined the possible association of DNMT1 polymorphisms with HBV clearance and the risk of hepatocellular carcinoma (HCC). Seven common polymorphic sites were selected by considering their allele frequencies, haplotype-tagging status and LDs for genotyping in larger-scale subjects (n = 1,100). Statistical analysis demonstrated that two intron polymorphisms of DNMT1, +34542G > C and +38565G > T, showed significant association with HBV clearance in a co-dominant model (OR = 1.30, Pcorr = 0.03) and co- dominant/recessive model (OR = 1.34-1.74, Pcorr = 0.01-0.03), respectively. These results suggest that two intron polymorphisms of DNMT1, +34542G > C and +38565G > T, might affect HBV clearance.

Cite

CITATION STYLE

APA

Chun, J. Y., Bae, J. S., Park, T. J., Kim, J. Y., Park, B. L., Cheong, H. S., … Shin, H. D. (2009). Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection. BMB Reports, 42(12), 834–839. https://doi.org/10.5483/BMBRep.2009.42.12.834

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free