Asymmetric synthesis of α-aminophosphonates using the inexpensive chiral catalyst 1,1'-binaphthol phosphate

Abstract

Asymmetric addition under mild conditions of dialkyl phosphites on aldimines derived from cinnamaldehyde catalyzed by the inexpensive chiral organocatalyst (R)-3,3'- [4-fluorophenyl]2-1,1'-binaphthol phosphate has been found effective to give new α- amino-phosphonates 9 in moderate yields (30-65%) and enantiomeric excess (8.4%-61.9%). © 2010 by the authors.