Association between Timing of Epinephrine Administration and Outcomes of Traumatic Out-of-Hospital Cardiac Arrest following Traffic Collisions

4Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

The effects of epinephrine administration timing on patients with out-of-hospital cardiac arrest (OHCA) following traffic collisions are unknown. We analyzed the 2013–2019 All-Japan Utstein Registry data of 2024 such patients aged ≥18 years who were resuscitated by emergency medical service (EMS) personnel or bystanders and then transported to medical institu-tions. Time from 119 call to epinephrine administration was classified into quartiles: Q1 (6–21 min), Q2 (22–26 min), Q3 (27–34 min), and Q4 (35–60 min). Multivariable logistic regression analysis was used to assess the effects of epinephrine administration timing on one-month survival after OHCA. Overall, the one-month survival rates were 3.2% (15/466) in Q1, 1.1% (5/472) in Q2, 1.9% (11/577) in Q3, and 0.2% (1/509) in Q4. Additionally, the one-month survival rate decreased significantly in the Q4 group (adjusted odds ratio, 0.07; 95% confidence interval, 0.01–0.57) compared with the Q1 group, and the probability of one-month survival decreased as the time from the EMS call to epinephrine administration increased (p-value for trend = 0.009). Only four patients (0.9% [4/466]) with the earliest epinephrine administration showed a good neurological outcome.

References Powered by Scopus

Cardiac arrest and cardiopulmonary resuscitation outcome reports: Update and simplification of the Utstein templates for resuscitation registries. A statement for healthcare professionals from a task force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian Resuscitation Council, New Zealand Resuscitation Council

1310Citations
N/AReaders
Get full text

Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication a consensus statement from the International Liaison Committee on Resuscitation

1265Citations
N/AReaders
Get full text

Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: The utstein style: A statement for health professionals from a task force of the American Heart Association, the European Resuscitation Council, and Heart and Stroke Foundation of Canada, and the Australian Resuscitation Council

1265Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Traumatic cardiac arrest

6Citations
N/AReaders
Get full text

Association between Timing of Epinephrine Administration and Outcomes of Traumatic Out-of-Hospital Cardiac Arrest following Traffic Collisions

4Citations
N/AReaders
Get full text

Approach to traumatic cardiac arrest in the emergency department: a narrative literature review for emergency providers

3Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Hosomi, S., Kitamura, T., Sobue, T., Zha, L., Kiyohara, K., Matsuyama, T., & Oda, J. (2022). Association between Timing of Epinephrine Administration and Outcomes of Traumatic Out-of-Hospital Cardiac Arrest following Traffic Collisions. Journal of Clinical Medicine, 11(12). https://doi.org/10.3390/jcm11123564

Readers' Discipline

Tooltip

Medicine and Dentistry 2

50%

Nursing and Health Professions 2

50%

Save time finding and organizing research with Mendeley

Sign up for free