Abstract
Ketamine, which has a similar chemical structure to phencyclidine, was first administered to humans in 1964 and found to produce a unique effect termed “dissociative anesthesia." In spite of the potential abuse liability, ketamine remains on the World Health Organization (WHO) Model List of Essential Medicines. It has been approved worldwide as the sole anesthetic agent for certain procedures, for the induction of anesthesia, and as an anesthetic supplement with low-potency agents like nitrous oxide. In addition, ketamine is also used for its analgesic properties in the management of cancer pain, chronic pain, and postoperative pain, among other indications. This chapter describes the history, development, clinical indications, and abuse potential of this agent.
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CITATION STYLE
Chang, L. C., Rajagopalan, S., & Mathew, S. J. (2016). The history of ketamine use and its clinical indications. In Ketamine for Treatment-Resistant Depression: The First Decade of Progress (pp. 1–12). Springer International Publishing. https://doi.org/10.1007/978-3-319-42925-0_1
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