Esophageal adenocarcinoma and its precursor Barrett’s esophagus have been rapidly increasing in incidence for half a century, for reasons not adequately explained by currently identified risk factors such as gastroesophageal reflux disease and obesity. The upper gastrointestinal microbiome may represent another potential cofactor. The distal esophagus has a distinct microbiome of predominantly oral-derived flora, which is altered in Barrett’s esophagus and reflux esophagitis. Chronic low-grade inflammation or direct carcinogenesis from this altered microbiome may combine with known risk factors to promote Barrett’s metaplasia and progression to adenocarcinoma.
CITATION STYLE
Snider, E. J., Freedberg, D. E., & Abrams, J. A. (2016, August 1). Potential Role of the Microbiome in Barrett’s Esophagus and Esophageal Adenocarcinoma. Digestive Diseases and Sciences. Springer New York LLC. https://doi.org/10.1007/s10620-016-4155-9
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