OBJECTIVE: To summarize current information on the relation between CD4 counts and the risk of different HIV-related diseases. MEASUREMENTS AND IN RESULTS: MEDLINE search of English language articles between 1985 and 1996 using the medical subject heading (MESH) term 'CD4 lymphocyte count' and searches using key words of multiple HIV-related diseases were conducted. Some HIV-related diseases can be stratified to different CD4 count levels. Regardless of their CD4 count, HIV-infected patients are susceptible to sinusitis, Kaposi's sarcoma, community-acquired pneumonia, and oral hairy leukoplakia. In advanced HIV, when CD4 is below 200/mm3, Pneumocystis carinii pneumonia, toxoplasmosis, progressive multifocal leukoencephalopathy, Mycobacterium avium complex, molluscum contagiosum, and bacillary angiomatosis all increase in incidence. In very advanced HIV disease, when CD4 counts are below 50/mm3, patients are at risk of pseudomonas pneumonia, cytomegalovirus retinitis, central nervous system lymphoma, aspergillosis, and disseminated histoplasmosis.
CITATION STYLE
Jung, A. C., & Paauw, D. S. (1998). Diagnosing HIV-related disease: Using the CD4 count as a guide. Journal of General Internal Medicine. https://doi.org/10.1046/j.1525-1497.1998.00031.x
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