Notch is a single-pass transmembrane receptor that mediates the local cell-cell interactions necessary for many cell-fate decisions. The extra cellular domain of Notch contains a tandem array of epidermal growth factor-like (EGF-like) repeats. Some of these EGF-like repeats are O-fucosylated by protein O-fucosyltransferase 1 (O-fut1), which is essential for Notch signaling in Drosophila and mouse. This O-fucose is further modified by Fringe, a GlcNAc transferase and other glycosyltransferases (O-fut1 in Drosophila and Pofut1 in mouse), to form an O-linked tetrasaccharide, which modulates Notch's selective binding to its ligands © 2012 Landes Bioscience and Springer Science+Business Media.
CITATION STYLE
Yamakawa, T., Ayukawa, T., & Matsuno, K. (2012). Metabolism and transportation pathways of GDP-fucose that are required for the O-fucosylation of notch. Advances in Experimental Medicine and Biology, 727, 37–46. https://doi.org/10.1007/978-1-4614-0899-4_3
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