Don't skip the G1 phase: How APC/CCdh1 keeps SCF Skp2 in check

Abstract

By keeping the levels of Skp2 and Cks1 low during G1 progression, APC/CCdh1 prevents unscheduled degradation of SCF Skp2 substrates and premature entry into S phase. Thus, APC/C Cdh1, a ubiquitin ligase involved in mitotic exit and maintenance of G0/G1 phase, directly controls SCFSkp2, a ubiquitin ligase involved in the regulation of S phase entry.