Collapsing networks: New avenues for functional connectivity analyses in multiple sclerosis

Abstract

Multiple sclerosis features extensive damage to both the grey and white matter. Over the years, studies have attempted to elaborate the specific mechanisms by which structural damage leads to complex symptoms like cognitive impairment. Recent advances in the field have highlighted the value of functional and structural network changes in multiple sclerosis. In this mini-review, some of these latest findings are discussed in the context of the hypothesis of a "network collapse", though to underlie clinical progression.