Retromer and the cation-independent mannose 6-phosphate receptor—Time for a trial separation?

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Abstract

The retromer cargo-selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR). Or does it? Recently published data have questioned the validity of this long-established theory. Here, the evidence for and against a role for the retromer CSC in CIMPR endosome-to-Golgi retrieval is examined in the light of the new data that the SNX-BAR dimer is actually responsible for CIMPR retrieval.

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Seaman, M. N. J. (2018). Retromer and the cation-independent mannose 6-phosphate receptor—Time for a trial separation? Traffic, 19(2), 150–152. https://doi.org/10.1111/tra.12542

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