The myoglobin technique measures oxygen tension in myocytes. It relies on a quantitative measurement of the Val E11 and His F8 signals and an accurate value for the [O2]50 for Mb. Even though the Mb oxygen affinity in the cell is in question, the NMR results still reflect the degree of Mb oxygen saturation. Although magnetic resonance has established a variety of strategies to measure tissue oxygenation, the Mb approach is the most direct and will lead to a better understanding of oxygen's role in regulating cellular activity.
CITATION STYLE
Jue, T., Kreutzer, U., & Chung, Y. (1994). 1H NMR approach to observe tissue oxygenation with the signals of myoglobin. In Advances in Experimental Medicine and Biology (Vol. 361, pp. 111–118). Springer New York LLC. https://doi.org/10.1007/978-1-4615-1875-4_15
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