Analysis of clinical efficacy of Si Miao decoction combine with acupuncture and cupping treatment for gout: a systematic review and meta-analysis

Abstract

This systematic review has been aimed to evaluate the clinical efficacy of the Si Miao decoction combined with acupuncture and cupping treatment for Gout. Three English and Chinese databases were searched for articles related to the effect of the Si Miao decoction combine with acupuncture and cupping therapy on CRP, UA, and ESR in Gout. The time period was limited from 01 January 2010 till 31 August 2019. Meta- analysis was performed using both the random and fixed effects model, and I 2 was used to evaluate the heterogeneity. Identification was made through database searching of 238 publications. Three articles were eligible.  Following the Si Miao Decoction combined with acupuncture and cupping therapy there was a significant reduction in the clinical parameters (SMD: −0.91, 95% CI: −1.081, −0.741, p = 0.000) (OR: −1.652, 95% CI: −1.960, −1.344, p = 0.000). High heterogeneity tests were indicated (Q=146.548, P = 0.00, I 2  = 94.54%). This systematic review and meta-analysis indicated that the Si Miao decoction combined with acupuncture and cupping therapy significantly reduced the circulating levels of UA, ESR, and CRP.  There is a need to improve the methodologies of clinical trials on modified Si Miao decoction combined with Acupuncture and Cupping treatment.