MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

113Citations
Citations of this article
193Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.

Cite

CITATION STYLE

APA

Ahmadi, S. E., Rahimi, S., Zarandi, B., Chegeni, R., & Safa, M. (2021, December 1). MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies. Journal of Hematology and Oncology. BioMed Central Ltd. https://doi.org/10.1186/s13045-021-01111-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free