Background: The measurement of respiratory system resistance during mechanical ventilation is important to ascertain the causes of increase in airway pressure during volume-controlled ventilation, which may include airways resistance and decreased respiratory system compliance. Discussion: Separation of total resistance from compliance of the respiratory system can be assessed by the end-inspiratory hold maneuver that separates peak pressure from plateau pressure. Conclusions: Although this method assumes a homogeneous respiratory system, it has proven useful clinically to separate flow-dependence issues such as bronchospasm or endotracheal tube obstruction from stiff lungs (acute lung injury) or decrease chest wall (abdominal distension) compliance.
CITATION STYLE
Guerin, C., & Richard, J. C. (2012). Measurement of respiratory system resistance during mechanical ventilation. In Applied Physiology in Intensive Care Medicine 1: Physiological Notes - Technical Notes - Seminal Studies in Intensive Care, Third Edition (pp. 17–20). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-28270-6_5
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