Patients with early stage high-risk prostate cancer (prostate specific antigen > 20, Gleason score > 7) are at high risk of recurrence following prostate cancer irradiation. Radiation dose escalation to the prostate may improve biochemical-free survival for these patients. However, high rectal and bladder dose with conventional three-dimensional conformal radiotherapy may lead to excessive gastrointestinal and genitourinary toxicity. Image-guided radiotherapy (IGRT), by virtue of combining the steep dose gradient of intensity-modulated radiotherapy and daily pretreatment imaging, may allow for radiation dose escalation and decreased treatment morbidity. Reduced treatment time is feasible with hypo-fractionated IGRT and it may improve patient quality of life.
CITATION STYLE
Nguyen, N. P., Davis, R., Bose, S. R., Dutta, S., Vinh-Hung, V., Chi, A., … Sroka, T. (2015). Potential applications of image-guided radiotherapy for radiation dose escalation in patients with early stage high-risk prostate cancer. Frontiers in Oncology. Frontiers Media S.A. https://doi.org/10.3389/fonc.2015.00018
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