Response Latency Tuning by Retinal Circuits Modulates Signal Efficiency

11Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

In the visual system, retinal ganglion cells (RGCs) of various subtypes encode preprocessed photoreceptor signals into a spike output which is then transmitted towards the brain through parallel feature pathways. Spike timing determines how each feature signal contributes to the output of downstream neurons in visual brain centers, thereby influencing efficiency in visual perception. In this study, we demonstrate a marked population-wide variability in RGC response latency that is independent of trial-to-trial variability and recording approach. RGC response latencies to simple visual stimuli vary considerably in a heterogenous cell population but remain reliable when RGCs of a single subtype are compared. This subtype specificity, however, vanishes when the retinal circuitry is bypassed via direct RGC electrical stimulation. This suggests that latency is primarily determined by the signaling speed through retinal pathways that provide subtype specific inputs to RGCs. In addition, response latency is significantly altered when GABA inhibition or gap junction signaling is disturbed, which further supports the key role of retinal microcircuits in latency tuning. Finally, modulation of stimulus parameters affects individual RGC response delays considerably. Based on these findings, we hypothesize that retinal microcircuits fine-tune RGC response latency, which in turn determines the context-dependent weighing of each signal and its contribution to visual perception.

References Powered by Scopus

The major cell populations of the mouse retina

1146Citations
N/AReaders
Get full text

The mechanism of directionally selective units in rabbit's retina.

1054Citations
N/AReaders
Get full text

Noise, neural codes and cortical organization

1002Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Simulating the impact of photoreceptor loss and inner retinal network changes on electrical activity of the retina

10Citations
N/AReaders
Get full text

The role of gap junctions in cell death and neuromodulation in the retina

10Citations
N/AReaders
Get full text

Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

7Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Tengölics, Á. J., Szarka, G., Ganczer, A., Szabó-Meleg, E., Nyitrai, M., Kovács-Öller, T., & Völgyi, B. (2019). Response Latency Tuning by Retinal Circuits Modulates Signal Efficiency. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-51756-y

Readers over time

‘19‘20‘21‘22‘23‘24‘2502468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 9

56%

Researcher 6

38%

Professor / Associate Prof. 1

6%

Readers' Discipline

Tooltip

Neuroscience 14

78%

Engineering 2

11%

Computer Science 1

6%

Agricultural and Biological Sciences 1

6%

Article Metrics

Tooltip
Mentions
References: 1

Save time finding and organizing research with Mendeley

Sign up for free
0