Clinical outcomes of thyroid tumours with concurrent epithelial and mesenchymal components in 14 dogs (2006–2020)

4Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: While rare, multiple individual case reports have described mixed thyroid tumours in dogs containing both epithelial and mesenchymal neoplastic components. Objectives: In this retrospective case series, we describe the clinical presentation, treatment and outcome of 14 dogs of canine thyroid tumours with concurrent mesenchymal and epithelial neoplastic populations. Methods: Fourteen cases were retrospectively abstracted from nine institutions. Histopathologic samples and reports were collected from 10/14 dogs and reviewed by a single board-certified anatomic pathologist. Results: All 14 dogs had curative-intent surgery to remove the thyroid neoplasm. The most common surgery performed was a unilateral thyroidectomy (10/14 dogs). Postoperatively, systemic therapy was administered in eight dogs. Six dogs developed local recurrence with a median time to loco-regional recurrence of 53 days. Ten dogs developed metastatic disease with the most common metastatic site being the lungs (6/10 dogs), with a median time to metastasis of 93 days. Ten dogs were euthanised due to locoregional or distant progression of their mixed thyroid neoplasm. The overall median survival time was 156 days (95%CI: 49–244). The median survival time for dogs treated with adjuvant therapy was 189 days (95%CI: 24–244), whereas dogs without adjuvant therapy had a median survival time of 156 days (95%CI: 35-upper limit could not be calculated; p = 0.62). Conclusion: The thyroid tumours with both mesenchymal and epithelial components in this small sample set were associated with a poor prognosis after surgical excision with or without adjunctive therapy.

Author supplied keywords

References Powered by Scopus

Classification and behavior of canine mammary epithelial neoplasms based on life-span observations in Beagles

141Citations
N/AReaders
Get full text

Prognostic Significance of Canine Mammary Tumor Histologic Subtypes: An Observational Cohort Study of 229 Cases

138Citations
N/AReaders
Get full text

Thyroid Tumors in Dogs and Cats

93Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Canine follicular cell and medullary thyroid carcinomas: Immunohistochemical characterization

1Citations
N/AReaders
Get full text

Effect of Changes in Canine Thyroid Cancer Terminology on Caregiver Anxiety Levels and Treatment Preferences in a Scenario-Based Study

0Citations
N/AReaders
Get full text

Prospective assessment of canine thyroid cancer—part I: nodal metastatic rate and impact of nodal immunohistochemistry in 70 dogs

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Cook, M. R., Gasparini, M., Cianciolo, R. E., Brown, M. E., Moore, A. S., Curran, K. M., … Selmic, L. E. (2022). Clinical outcomes of thyroid tumours with concurrent epithelial and mesenchymal components in 14 dogs (2006–2020). Veterinary Medicine and Science, 8(2), 509–516. https://doi.org/10.1002/vms3.703

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

50%

Professor / Associate Prof. 1

17%

Lecturer / Post doc 1

17%

Researcher 1

17%

Readers' Discipline

Tooltip

Veterinary Science and Veterinary Medic... 10

91%

Biochemistry, Genetics and Molecular Bi... 1

9%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 23

Save time finding and organizing research with Mendeley

Sign up for free