Bronchial hyperresponsiveness in an adult population in Helsinki: Decreased FEV1, the main determinant

12Citations
Citations of this article
32Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Introduction: Bronchial hyperresponsiveness (BHR) elevates the risk for development of respiratory symptoms and accelerates the decline in forced expiratory volume in the first second (FEV1). We thus aimed to assess the prevalence, determinants and quantity of BHR in Helsinki. Objectives: This study involved 292 randomly selected subjects age 26-66years, women comprising 58%. Methods: Following a structured interview, a spirometry, a bronchodilation test, and a skin-prick test, we assessed a bronchial challenge test with inhaled histamine using a dosimetric tidal breathing method. Results included the provocative dose inducing a decrease in FEV1 by 15% (PD15FEV1) and the dose-response slope. For statistical risk factor-analyses, the severity of BHR was considered; PD15 values ≤1.6mg (BHR) and ≤0.4mg [moderate or severe BHR (BHRms)] served as cut-off levels. Results: BHR presented in 21.2% and BHRms in 6.2% of the subjects. FEV1<80% of predicted [odds ratio (OR) 4.09], airway obstruction (FEV1/forced vital capacity<88% of predicted) (OR 4.33) and history of respiratory infection at age <5 (OR 2.65) yielded an increased risk for BHR as ORs in multivariate analysis. For BHRms, the determinants were decreased FEV1 below 80% of predicted (OR 27.18) and airway obstruction (OR 6.16). Respiratory symptoms and asthma medication showed a significant association with BHR. Conclusions: Of the adult population of Helsinki, 21% showed BHR to inhaled histamine. The main determinants were decreased FEV1 and airway obstruction. Quantitative assessment of BHR by different cut-off levels provides a tool for characterization of phenotypes of airway disorders in epidemiologic and clinical studies. Please cite this paper as: Juusela M, Pallasaho P, Sarna S, Piirilä P, Lundbäck B and Sovijärvi A. Bronchial hyperresponsiveness in an adult population in Helsinki: decreased FEV1, the main determinant. © 2011 Blackwell Publishing Ltd.

Cite

CITATION STYLE

APA

Juusela, M., Pallasaho, P., Sarna, S., Piirilä, P., Lundbäck, B., & Sovijärvi, A. (2013). Bronchial hyperresponsiveness in an adult population in Helsinki: Decreased FEV1, the main determinant. Clinical Respiratory Journal, 7(1), 34–44. https://doi.org/10.1111/j.1752-699X.2012.00279.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free