Current research and new perspectives in antifungal drug development

Abstract

In recent times, fungi are becoming more and more active as causal agents of human infections, which is primarily determined by the growing number of people with severe immunosuppression. Thus, the problems of elucidating the mechanisms of action of antifungal preparations, highlighting ways to obtain resistance to their action and research strategies aimed at discovering new compounds with antifungal properties remain the focus of contemporary biomedicine and pharmaceutics. This paper reviews the recent achievements in antifungal drug development and focuses on new natural antifungal remedies with a noticeable effect on pathogens with minimal adverse effects on the host organism.