MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients

Abstract

Background: Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. Methods: We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. Results: A high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (1306C>T) and MMP-9 (1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification. Conclusion: MMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients. © 2012 Cancer Research UK All rights reserved.