Intercellular Communication, the Tumor Microenvironment, and Tumor Progression

Abstract

Within a solid tumor, cancer cells interact with normal host cells as well as with insoluble and soluble factors, including extracellular matrix proteins and chemokines. Here, we survey the molecular mechanisms by which cancer cells interact with their surrounding microenvironment, with a particular focus on intercellular communication. This host-tumor crosstalk provides key signals that direct the growth, migration, and dissemination of cancer cells. Approaches that disrupt or coopt intercellular communication between the tumor and its host are exciting and potentially powerful anti-cancer therapeutic strategies.