Microencapsulation of ascorbic acid for cosmetic by utilizing self-assembly of phase separated polymer

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Abstract

Micrometer-sized polymer particles encapsulated ascorbic acid (vitamin C; VC) were successfully prepared by the three types of the self-assembling method, those are, phase separation and self-assembly of added polymer at the oil-water interface in emulsion, microsuspension polymerization utilizing the self-assembling of phase separated polymer (SaPSeP) method, and their hybrid method. In the stability study at 50°C for 2 months, the three kinds of capsule particles exhibited effective protection of VC from the interaction with other components in cosmetic consisting of water-in-oil (W/O) emulsion. The encapsulated VC was easily released from the capsule particles by an excess of water. These encapsulation methods will be useful for the stabilization of water-soluble substances in cosmetic consisting of W/O emulsion.

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Nakai, S., Nakai, A., & Michida, T. (2016). Microencapsulation of ascorbic acid for cosmetic by utilizing self-assembly of phase separated polymer. Chemical and Pharmaceutical Bulletin, 64(10), 1514–1518. https://doi.org/10.1248/cpb.c16-00384

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