Polyphenol in olive oil: A promising adjuvant therapeutic agent in wound healing management and wound complication prevention

Abstract

Wound is one of the most common findings in medical problems. Tissue repairment would return tissue integrity normally in morphology and function, but in certain cases, tissue repairment could be disrupted or uncontrolled. Disrupted tissue repair by infection agents, inadequate treatment, or other risk factors would lead to complications such as ulcers, gangrene, tissue death, or hypertrophic scar. These complications could lead to physical, mental, social, aesthetic, and financial burdens. Olive oil is a substance extracted from whole olive fruits widely used in the culinary world. Olive oil in skin treatment has been used since ancient times, and current research has developed in olive oil as an adjuvant treatment. Several researches have resulted in a positive result for olive oil as a promising agent for wound treatment to emulate tissue regeneration and prevent wound complications. According to several studies, flavonoids, oleuropein, phenolic acids, phenolic alcohols, lignans, and other compounds contribute as antioxidant and anti-inflammatory compounds. Certain substances in olive oil contribute as a cell protector, antimicrobial, and anticarcinogenic, which are important aspects of wound management, tissue recovery and complication prevention. These substances are found in eliminating oxidative species, lowering inflammatory responses, and inducing protein synthesis in tissue regeneration.