Major strengths of mass spectrometry analysis include the accuracy of the detection principle, automatic data storage as well as simplicity and flexibility of assay design making it a premier choice for targeted genotyping of sequence variations. We explain the assay principle in detail and give step-by-step laboratory instructions. Finally, references point toward further use of mass spectrometry analysis for molecular haplotyping, re-sequencing, and quantitative analysis for copy number variations and gene expression studies are given. © Springer Science+Business Media, LLC 2013.
CITATION STYLE
Van Den Boom, D., Wjst, M., & Everts, R. E. (2013). MALDI-TOF mass spectrometry. Methods in Molecular Biology, 1015, 71–85. https://doi.org/10.1007/978-1-62703-435-7_4
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