Accurate on-line estimation of delivered dialysis dose by dialysis adequacy monitor (DIAMON)

Abstract

The aim of this study was to compare equilibrated urea Kt/V (eKt/V) from the slope of the logarithmic online UV-absorbance measurements measured by the Dialysis Adequacy Monitor (DIAMON), by eKt/V obtained from a new algorithm that can be implemented into the DIAMON prototype. As the reference the urea eKt/V was utilized obtained from the blood samples according to the rate adjustment method. The mean value of equilibrated Kt/V obtained with UV-absorbance (eKt/Va) was 1.06 ± 0.21, using the new algorithm (eKt/Vn) was 1.09 ± 0.18, and eKt/V from blood-urea (eKt/Vb) 1.09 ± 0.20 (N = 21). The mean values of eKt/V were not statistically different comparing different methods. However, both the systematic and the random error were diminished by the new algorithm. The systematic error was decreased from 2.19% to 0.312%, and the random error was decreased from 14.37% to 7.30% using the new algorithm. In summary, the DIAMON prototype can accurately and on-line estimate the dialysis dose.