Determination of Cystatin C Level in a Sample of Patients with Chronic Kidney Disease

Abstract

Chronic kidney disease (CKD) effects around one-third of the population and is frequently under recognized by patients and clinicians. GFR of less than 60 mL/min/1.73 m2, A minimum of 30 mg of albuminuria per 24 hours, Hematuria or structural abnormalities are signs of kidney damage such like polycystic kidney disease or dysplastic kidneys that persists for more than 3 months. The purpose of this research was to examine the efficacy of cystatin C as a measure of renal function in individuals. Cystatin C, Creatinine, urea, and uric acid levels were measured in 225 blood samples (150 patients and 75 controls). Cystatin C was measured as enzymatic link absorbance assay and the measurements of urea, creatinine, and uric acid were performed using the Cobas c311. Cystatin C levels, urea, serum creatinine, and uric acid were found to show high significant differences (p <0.01) between the patient and control. Cystatin C is useful to detect individuals with CKD who show a little reduction in GFR as compared to serum creatinine. Serum Cystatin C, urea, uric acid, and Creatinine levels all rise as eGFR falls. Serum Cystatin C could be utilized to evaluate people who have poorly managed diabetes mellitus or high blood pressure when the serum creatinine level is inconclusive.