Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity

6Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry cause autoreactive T cells to cross-activate. The aim of the current study was to implement immunoinformatics approaches to infer sequence- and structure-based molecular mimicry between viral and human proteomic datasets. The protein sequences of all the so far known human-infecting viruses were obtained from the VIPR database, and complete human proteome data were retrieved from the NCBI repository. Based on a predefined, stringent threshold of comparative sequence analyses, 24 viral proteins were identified with significant sequence similarity to human proteins. PathDIP identified the enrichment of these homologous proteins in nine metabolic pathways with a p-value < 0.0001. Several viral and human mimic epitopes from these homologous proteins were predicted as strong binders of human HLA alleles, with IC50 < 50 nM. Downstream molecular docking analyses identified that lead virus-human homologous epitopes feasibly interact with HLA and TLR4 types of immune receptors. The vast majority of these top-hit homolog epitopic peptides belong to the herpes simplex and poxvirus families. These lead epitope biological sequences and 3D structural-based molecular mimicry may be promising for interpreting herpes simplex virus and poxvirus infection-mediated autoimmune disorders in humans.

References Powered by Scopus

UCSF Chimera - A visualization system for exploratory research and analysis

35317Citations
N/AReaders
Get full text

NCBI BLAST: a better web interface.

3072Citations
N/AReaders
Get full text

The ClusPro web server for protein-protein docking

2109Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Molecular mimicry as a mechanism of viral immune evasion and autoimmunity

3Citations
N/AReaders
Get full text

Molecular Mimicry Mapping in Streptococcus pneumoniae: Cues for Autoimmune Disorders and Implications for Immune Defense Activation

3Citations
N/AReaders
Get full text

Viruses as a potential environmental trigger of type 1 diabetes mellitus (Review)

2Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Begum, S., Aiman, S., Ahmad, S., Samad, A., Almehmadi, M., Allahyani, M., … Khan, A. (2022). Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity. Pathogens, 11(11). https://doi.org/10.3390/pathogens11111362

Readers over time

‘22‘23‘24‘2500.751.52.253

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

60%

Lecturer / Post doc 1

20%

Researcher 1

20%

Readers' Discipline

Tooltip

Medicine and Dentistry 2

40%

Immunology and Microbiology 2

40%

Biochemistry, Genetics and Molecular Bi... 1

20%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free
0