Much has been learned about how HIV-induced immune dysfunction contributes to B cell hyperactivation, and potentially, to the pathogenesis of AIDS-lymphoma. However, further studies are needed to fully understand how HIV infection and immune dysfunction promote B cell hyperactivation and the development/growth of AIDS-lymphoma. In particular, studies are needed to define the role of HHV8 vIL6, IL6 receptor-expression, and lymphocyte surface stimulatory molecules, in promoting B cell hyperactivation or lymphoma cell growth.
CITATION STYLE
Martínez-Maza, O., Widney, D., Van Der Meijden, M., Knox, R., Echeverri, A., Breen, E. C., … Miles, S. A. (1998). Immune Dysfunction and the Pathogenesis of AIDS-associated non-Hodgkin’s Lymphoma. Memorias Do Instituto Oswaldo Cruz, 93(3), 373–381. https://doi.org/10.1590/S0074-02761998000300019
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