Modern life sciences are becoming increasingly data intensive, posing a significant challenge for most researchers and shifting the bottleneck of scientific discovery from data generation to data analysis. As a result, progress in genome research is increasingly impeded by bioinformatic hurdles. A new generation of powerful and easy-to-use genome analysis tools has been developed to address this issue, enabling biologists to perform complex bioinformatic analyses online - without having to learn a programming language or downloading and manually processing large datasets. In this tutorial paper, we describe the use of EpiGRAPH (http://epigraph.mpi-inf.mpg.de/) and Galaxy (http://galaxyproject.org/) for genome and epigenome analysis, and we illustrate how these two web services work together to identify epigenetic modifications that are characteristics of highly polymorphic (SNP-rich) promoters. This paper is supplemented with video tutorials (http://tinyurl.com/yc5xkqq), which provide a step-by-step guide through each example analysis. © 2010 Springer Science + Business Media, LLC.
CITATION STYLE
Bock, C., Von Kuster, G., Halachev, K., Taylor, J., Nekrutenko, A., & Lengauer, T. (2010). Web-based analysis of (Epi-) genome data using EpiGRAPH and galaxy. Methods in Molecular Biology, 628, 275–296. https://doi.org/10.1007/978-1-60327-367-1_15
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