Boron in Aging and Longevity

Abstract

OnlyLongevitylimited directAgingevidence from Drosophila studies exists to indicate that boron promotes healthy agingAgingand longevityLongevity. However, substantial indirect evidence supports the suggestion that boron does have such an effect. Boron has bioactivity that affects the formation and activity NAD+ and SAM, which have been shown to affect agingAgingand longevityLongevity. Evidence has been provided to indicate, that through affecting these two biomolecules, boron has beneficial effects on inflammatory and oxidative stressOxidative stress, DNA damageDNA damagedetection and repair, and SAM involvement in methylation and homocysteineHomocysteinelevels. Through these effects, nutritional intakes of boron have been shown to moderate or alleviate several pathological conditions associated with agingAging, including cancerCancer, cognitive decline, sarcopeniaSarcopenia, and boneBonehealthHealth. These findings indicate that a diet rich in boron will promote healthy agingAgingand longevityLongevity.