Anti-Tubercular Activities and Molecular Characterization of Salivary Extract of Leech ( Hirudo medicinalis) against Mycobacterium tuberculosis

  • Ojo P
  • Babayi H
  • Olayemi I
  • et al.
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Abstract

Leech salivary extract (LSE) was screened for the anti-tubercular activity against Mycobacterium tuberculosis using microbroth dilution method. The bioactive components in LSE were determined using Shimadzu GC-MS QP2010 SE. The LSE exhibited bactericidal effects on M. tuberculosis at 50% (v/v). The result of the GC-MS analysis of LSE revealed seventeen (17) bioac-tive components. The major fatty acid components were oleic acid (33.9%) and palmitic acid also known as hexadecanoic acid (22.6%). Other bioactive components detected in appreciable amounts in LSE include, 4-bromobutyric acid (16.86%), 6,17-Octadiene-1-ol acetate (9.78%) and octahydro-1,4,9,9-tetramethyl (5.21%). The anti-tubercular activity of the LSE was attributed to these bioactive components. The results obtained suggest that leech salivary extract could be used in treating tuberculosis.

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APA

Ojo, P. O., Babayi, H., Olayemi, I. K., Peter, O. O., Fadipe, L. A., Baba, E., & Izebe, K. (2018). Anti-Tubercular Activities and Molecular Characterization of Salivary Extract of Leech ( Hirudo medicinalis) against Mycobacterium tuberculosis. Journal of Tuberculosis Research, 06(01), 1–9. https://doi.org/10.4236/jtr.2018.61001

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