Phosphorylation of ULK1 serine 746 dictates ATG5-independent autophagy

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Abstract

There is a type of noncanonical autophagy, which is independent of ATG5 (autophagy related 5), also referred to as alternative autophagy. Both canonical and ATG5-independent alternative autophagy require the initiator ULK1 (unc-51 like kinase 1), but how ULK1 regulates these two types of autophagy differently remains unclear. A recent paper from Torii et al. demonstrates that phosphorylation of ULK1 at Ser746 by RIPK3 (receptor interacting serine/threonine kinase 3) is the key difference between these two types of autophagy; this phosphorylation is exclusively found during alternative autophagy.

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Wen, X., & Klionsky, D. J. (2020, September 1). Phosphorylation of ULK1 serine 746 dictates ATG5-independent autophagy. Autophagy. Taylor and Francis Inc. https://doi.org/10.1080/15548627.2020.1780844

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