Potassium iodate (KIO 3) as a novel reagent for the synthesis of isoxazolines: evaluation of antimicrobial activity of the products

Abstract

Abstract : A novel reagent for the synthesis of isoxazolines has been reported. Aryl aldoximes were made to react with alkenes in the presence of KIO 3 as the oxidising agent. This new reagent has been useful as an oxidant in the synthesis of isoxazoline and its function is attributed to the generation of nitrile oxide, which is an important intermediate for the synthesis of the valuable heterocycle like isoxazoline. Graphical Abstract : SYNOPSIS A novel reagent for the synthesis of isoxazolines has been reported. Aryl aldoximes were treated with alkenes in the presence of KIO 3 as the oxidising agent to obtain isoxazolines. [Figure not available: see fulltext.].