Mouse hepatitis virus type 3 (MHV3) appears to be an excellent model for the study of the relationship between viral-induced immunodeficiency and the development of chronic disease. Animal surviving acute hepatitis develop a chronic disease characterized by viral persistency in various organs, by a humoral immunodeficiency, and eventually die within the next three months postinfection. To verify if B cell immunodeficiency occurs during the chronic disease, percentage and absolute number of bone marrow B lineage cell subpopulations were recorded at various times postinfection (p.i.) in pathogenic L2-MHV3-infected (C57BL/6 x A/J) F1 mice. Absolute numbers of B (Cμ+ sμ+) cells decreased as early as three days p.i. up to 15 days p.i., and then gradually returned toward normal values in L2-MHV3-infected mice during the chronic disease. In contrast, pre-B (cμ+ sμ-) cells were less significantly decrease during the chronic disease. In addition, abnormally enlarged cells (> 13 μm) were detected either in bone marrow pre-B or B cells from L2-MHV3-infected mice.
CITATION STYLE
Jolicoeur, P., & Lamontagne, L. (1995). Impairment of bone marrow pre-B and B cells in MHV3 chronically-infected mice. In Advances in Experimental Medicine and Biology (Vol. 380, pp. 193–195). Springer New York LLC. https://doi.org/10.1007/978-1-4615-1899-0_33
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