Cardiac troponin and COVID-19 severity: Results from BIOCOVID study

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Abstract

Background: Myocardial injury is a common finding in COVID-19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID-19 patients, and further evaluated separately the role of troponin T and I. Methods: This is a multicentre, retrospective observational study enrolling patients with laboratory-confirmed COVID-19 who were hospitalized in 32 Spanish hospitals. Elevated troponin levels were defined as values above the sex-specific 99th percentile upper reference limit, as recommended by international guidelines. Thirty-day mortality was defined as endpoint. Results: A total of 1280 COVID-19 patients were included in this study, of whom 187 (14.6%) died during the hospitalization. Using a nonspecific sex cut-off, elevated troponin levels were found in 344 patients (26.9%), increasing to 384 (30.0%) when a sex-specific cut-off was used. This prevalence was significantly higher (42.9% vs 21.9%; P

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García de Guadiana-Romualdo, L., Morell-García, D., Rodríguez-Fraga, O., Morales-Indiano, C., María Lourdes Padilla Jiménez, A., Gutiérrez Revilla, J. I., … Consuegra-Sánchez, L. (2021). Cardiac troponin and COVID-19 severity: Results from BIOCOVID study. European Journal of Clinical Investigation, 51(6). https://doi.org/10.1111/eci.13532

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