A new electrochemical system for stereoselective allylic hydroxylation of cholesteryl acetate with dioxygen induced by iron picolinate complexes

Abstract

The oxygenation reaction of cholesteryl acetate 1 was examined with the FeIII(PA)3/O2/MeCN system using an electrochemical method. The constant potential technique gave mainly the 7-hydroxylated product stereoselectively, along with the 7-oxo product. This oxygenation system is mechanistically unique, requiring iron catalyst, dioxygen, and both cathode and anode. © 2004 Pharmaceutical Society of Japan.