Innate immunity of spondyloarthritis: The role of toll-like receptors

Abstract

Amongst the spondyloarthroparhies (SpA), the relationship of host susceptibility and environmental triggers is best seen in reactive arthritis (ReA).There are several points from the clinical studies of ReA which highlight important unresolved issues in the pathogenesis. Innate and adaptive immune responses are distinct, but complementary aspects of host defense (Pacheco-Tena et al, 2002. Beutler et al, 2006). Innate immunity is critically dependent upon non variant, geneticallyencoded receptors for highly conserved structures known aspathogen-associated molecular patterns (PAMP). The receptors themselves are termed pattern-recognition receptors (PRR). Among the PRR, toll-like receptors (TLR) playa central role. © 2009 Landes Bioscience and Springer Science+Business Media.