Artificial immune system for classification of cancer

Abstract

This paper presents a method for cancer type classification based on microarray-monitored data. The method is based on artificial immune system(AIS), which utilizes immunological recognition for classification. The system evolutionarily selects important genes; optimize their weights to derive classification rules. This system was applied to gene expression data of acute leukemia patients to classify their cancer class. The primary result found few classification rules which correctly classified all the test samples and gave some interesting implications for feature selection principles. © Springer-Verlag Berlin Heidelberg 2003.