A total synthesis of (-)-strempeliopine is disclosed that enlists a powerful SmI2-mediated and BF3·OEt2-initiated dearomative transannular radical cyclization onto an indole by an N-acyl α-aminoalkyl radical that is derived by single electron reduction of an in situ generated iminium ion for formation of a quaternary center and the strategic C19-C2 bond in its core structure.
CITATION STYLE
Zeng, X., & Boger, D. L. (2021). Total Synthesis of (-)-Strempeliopine. Journal of the American Chemical Society, 143(31), 12412–12417. https://doi.org/10.1021/jacs.1c06913
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