MIR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression

Abstract

While MIR-204 expression may be linked to renal cell carcinoma (RCC) progression, the detailed mechanisms remain unclear. In the present study, we demonstrated that MIR-204 was differentially expressed in RCC tissues when compared with surrounding normal kidney tissues. Ectopic overexpression of MIR-204 in human RCC cells suppressed cell proliferation and invasion in vitro and in vivo. Mechanism dissection revealed that MIR-204 may function through RAB22A signals to inhibit RCC proliferation and invasion. Overexpression of RAB22A by oe-RAB22A was able to partially reverse the MIR-204-mediated suppression of RCC tumor progression. Together, these results revealed that MIR-204 suppressed RCC proliferation and invasion by directly targeting the RAB22A gene. Targeting newly identified RAB22A with MIR-204 may aid in the suppression of RCC proliferation and invasion.